Hydrochlorothiazide

It is commonly used to treat high blood pressure and edema caused by fluid accumulation. Other uses include treating diabetes insipidus and renal tubular acidosis, and it may also reduce hypercalciuria, thereby reducing the risk of kidney stones. In addition, this drug is often used as a first-line drug for the treatment of high blood pressure. Hydrochlorothiazide is an oral drug that is sometimes mixed with other blood pressure-lowering drugs to make compound pills to enhance the effect of the drug.

(1) Edema diseases: including congestive heart failure, liver cirrhosis ascites, nephrotic syndrome, acute and chronic nephritis edema, early chronic renal failure, sodium and water retention caused by adrenocortical hormone and estrogen therapy.

(2) Hypertension: It can be used alone or in combination with other antihypertensive drugs, mainly for the treatment of essential hypertension.

(3) Central or nephrogenic diabetes insipidus.

(4) Nephrolithiasis: It is mainly used to prevent stones formed by calcium salts.

USP, EP

5-chloro-2,4-chlorosulfonylaniline is obtained by chlorosulfonation of m-chloroaniline, and then reacted with ammonia to generate 5-chloro-2,4-sulfamic acid aniline, and finally obtained by distorting formaldehyde.

USDMF, GMP.